Overview
SCIENTIFIC SCORE
Questionable
Based on 44 Researches
6.6
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
9
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Read More
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
8
We examined whether serum magnesium levels at admission could predict in-hospital outcomes for patients experiencing a heart attack.
In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.
Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.
In our study of 259 acute myocardial infarction patients, those with lower magnesium levels (below 1.82 mg/dl) faced significantly higher risks of complications, including arrhythmias and even death, compared to those with healthier levels.
Our findings suggest that maintaining adequate magnesium levels is essential for better health outcomes after a heart attack.
Read More
Most Useful Reviews
9.5
Normalised rhythm
This product is excellent for the heart; it normalises the rhythm. If you’re taking tablets for hypertension, it's best to consume Ca.Mg.Zn in the evening, as combining everything might cause a heart attack, although this varies from person to person.
Read More
9.5
No more cramps
Since taking this product, my heart attack symptoms, including painful leg cramps at night, have vanished. I had been ill since my 20s with angina, but this complex worked where singular supplements failed. iHerb is fantastic!
Read More
9
Stronger bones
I found online that this calcium, magnesium, zinc, and vitamin D3 complex strengthens bones, teeth, and nails while supporting heart function. Magnesium enhances calcium absorption while vitamin D3 helps maintain calcium levels. After using it, I feel less fatigued, sleep better, and my nails have become much stronger!
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 44 Researches
6.6
- All Researches
9
We explored how calcium signaling influences heart cell proliferation, particularly after injuries like heart attacks. Our study centered on the L-Type Calcium Channel (LTCC) and how its inhibition might help heart cells regenerate. Remarkably, when we inhibited LTCC—either through pharmacological means or by enhancing the activity of an inherent inhibitor called RRAD—we observed significant boosts in heart cell activity.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
This process appears connected to calcineurin activity, a key player in cell signaling. By carefully manipulating these pathways, we managed to not only provoke heart cell growth in lab settings but also improve heart function and reduce scar tissue in live animal models post-heart attack.
Through our findings, we highlight the potential for new calcium-related treatments that could significantly benefit patients with heart injury, paving the way for exciting advancements in regenerative medicine. By understanding this intricate relationship between calcium signaling and heart cell growth, we open doors for innovative therapies that could transform recovery strategies in cardiovascular care.
Read More
9
Vitamin D and activity improve survival
We examined how vitamin D status and physical activity (PA) relate to long-term survival following a heart attack, also known as a myocardial infarction (MI). In our analysis of 4,837 MI patients, we measured the levels of vitamin D in their blood and assessed their physical activity using a reliable questionnaire.
Over an average follow-up of 14.4 years, we observed that higher vitamin D levels were linked to a significant reduction in both cardiovascular (CVD) and all-cause mortality. Specifically, patients with adequate vitamin D levels had about 37% lower risk of CVD-related deaths compared to those with lower levels. Additionally, engaging in more physical activity also correlated with a lower mortality risk.
Importantly, we found that those with low vitamin D levels and little to no physical activity faced a threefold increased risk of mortality compared to patients who had high vitamin D levels and were active. These findings suggest that both vitamin D and physical activity independently contribute to improving survival rates post-heart attack, regardless of other health factors.
Overall, this study underscores the importance of monitoring vitamin D levels and encouraging physical activity to enhance recovery and longevity after a heart attack.
Over an average follow-up of 14.4 years, we observed that higher vitamin D levels were linked to a significant reduction in both cardiovascular (CVD) and all-cause mortality. Specifically, patients with adequate vitamin D levels had about 37% lower risk of CVD-related deaths compared to those with lower levels. Additionally, engaging in more physical activity also correlated with a lower mortality risk.
Importantly, we found that those with low vitamin D levels and little to no physical activity faced a threefold increased risk of mortality compared to patients who had high vitamin D levels and were active. These findings suggest that both vitamin D and physical activity independently contribute to improving survival rates post-heart attack, regardless of other health factors.
Overall, this study underscores the importance of monitoring vitamin D levels and encouraging physical activity to enhance recovery and longevity after a heart attack.
Read More
9
We explored the potential of magnesium implantation as a new approach to combat heart attacks, specifically myocardial infarction (MI). Our research centered on using magnesium slices implanted under the skin of rats to generate hydrogen gas continuously. This method could ensure a greater and longer-lasting concentration of hydrogen directly reaching the heart, which is crucial for its therapeutic effects.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Through our study, we measured how effectively the magnesium produced hydrogen and evaluated its safety. The results were promising; we observed that magnesium implantation not only improved cardiac function in rats suffering from MI, but also played a role in eliminating harmful free radicals from mitochondrial dysfunction. Furthermore, it helped reduce cell death in heart muscle cells, which is a common consequence of heart attacks.
Compared to traditional hydrogen inhalation, which has limitations in delivering sufficient doses over time, magnesium implantation proved to be a superior method. Overall, our findings pave the way for innovative treatments that could enhance recovery after heart attacks by harnessing the unique properties of magnesium for hydrogen production.
Read More
9
Magnesium scaffolds improve heart attack outcomes
We examined the performance of two types of bioresorbable scaffolds in patients experiencing acute coronary syndrome (ACS) - a common and serious manifestation of heart disease. Specifically, we compared the effectiveness of magnesium-based scaffolds, known as Magmaris, with the earlier polymer scaffolds called Absorb.
Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.
Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.
Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
Our study included 193 patients using Magmaris and 160 patients using Absorb, all treated in similar clinical settings. Over the course of one year, we monitored their health outcomes, particularly focusing on serious issues like cardiac death, heart attacks, and instances of scaffold thrombosis.
Surprisingly, we found that patients with Magmaris had significantly better outcomes than those with Absorb. Specifically, the rates of primary complications and target lesion failures were notably lower with Magmaris. We noted a concerning trend with Absorb, where patients experienced a higher rate of scaffold thrombosis.
Overall, our findings suggest that magnesium-based scaffolds could provide a safer and more effective option for patients undergoing treatment for heart attacks compared to their polymer counterparts.
Read More
We aimed to explore how zinc oxide nanoparticles (ZnO NPs) could protect the heart from damage caused by doxorubicin, a drug that can lead to serious heart issues, including myocardial infarction (MI). Our study involved rats that were injected with doxorubicin to induce MI and then treated with ZnO NPs at two different doses.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Throughout the research, we observed significant improvements in heart health among the rats that received these nanoparticles. Specifically, their heart function showed recovery, with important biochemical markers reflecting less damage. The lower dose of ZnO NPs was especially effective, aiding the antioxidant system and boosting nitric oxide production, which is vital for heart function.
Our findings suggest that ZnO NPs could be a promising way to counteract the cardiotoxic effects of doxorubicin. This insight opens new avenues for treatment strategies aimed at patients who need chemotherapy without risking their heart health.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Normalised rhythm
This product is excellent for the heart; it normalises the rhythm. If you’re taking tablets for hypertension, it's best to consume Ca.Mg.Zn in the evening, as combining everything might cause a heart attack, although this varies from person to person.
Read More
9.5
No more cramps
Since taking this product, my heart attack symptoms, including painful leg cramps at night, have vanished. I had been ill since my 20s with angina, but this complex worked where singular supplements failed. iHerb is fantastic!
Read More
9
Stronger bones
I found online that this calcium, magnesium, zinc, and vitamin D3 complex strengthens bones, teeth, and nails while supporting heart function. Magnesium enhances calcium absorption while vitamin D3 helps maintain calcium levels. After using it, I feel less fatigued, sleep better, and my nails have become much stronger!
Read More
8.8
Reduced numbness
I haven't taken Magnesium for a while, as my cardiologist prescribed it to help with my heart attack alongside Mildronate (meldonium). After nearly a month of use, I noticed my left leg stopped going numb. While my hands still occasionally go numb, I see slight improvements! I'll try a different brand soon. Thanks for the available products!
Read More
3.5
Reduced palpitations
I consumed half a serving, and I’m pleased to say that my heart palpitations are gone.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Balasubramanian A, Kunchala K, Shahbaz A, Kar A, Sankar J, et al. Association of Vitamin D Deficiency as an Independent Risk Factor for Myocardial Infarction and Its Therapeutic Implications: A Systematic Review. Cureus. 2025;17:e77375. doi:10.7759/cureus.77375
- Li Q, Tong Y, Guo J, Liang X, Shao H, et al. Vitamin D Receptor Regulates Oxidative Stress and Apoptosis Via the HIF-1α/HO-1 Pathway in Cardiomyocytes. Cell Biochem Biophys. 2025. doi:10.1007/s12013-025-01681-x
- Olędzki S, Siennicka A, Maciejewska-Markiewicz D, Stachowska E, Jakubiak N, et al. Calcitriol Concentration in the Early Phase of Myocardial Infarction and Its Relation to Left Ventricular Ejection Fraction. Metabolites. 2024;14. doi:10.3390/metabo14120686
- Cruijsen E, van Pijkeren CS, Evers I, Visseren FLJ, Geleijnse JM. Vitamin D status, physical activity and long-term mortality risk after myocardial infarction: a prospective analysis in the Alpha Omega Cohort. Eur J Prev Cardiol. 2024. doi:10.1093/eurjpc/zwae359
- Chin WC, Huang YS, Wu LS, Lee KT, Ho CT, et al. The Prognosis of Patients with Myocardial Infarction after Light Therapy: A Preliminary Study. Biomed J. 2024. doi:10.1016/j.bj.2024.100783
- Kocaman N. Evaluating the therapeutic effect of vitamin D and nerolidol on lung injury due to experimental myocardial infarction: The potential role of asprosin and spexin. Tissue Cell. 2024;89:102444. doi:10.1016/j.tice.2024.102444
- Gaggini M, Marchi F, Pylypiv N, Parlanti A, Storti S, et al. Vitamin D and Ceramide Metabolomic Profile in Acute Myocardial Infarction. Metabolites. 2024;14. doi:10.3390/metabo14040233
- Zhao S, Chen X, Wan Z, Geng T, Lu Q, et al. Associations of serum 25-hydroxyvitamin D and vitamin D receptor polymorphisms with risks of cardiovascular disease and mortality among patients with chronic kidney disease: a prospective study. Am J Clin Nutr. 2024;119:1397. doi:10.1016/j.ajcnut.2024.04.001
- Yaman AE, Ceylan US. Effects of Vitamin D Levels on Long-Term Coronary Events in Patients with Proven Coronary Artery Disease: Six-Year Follow-Up. J Clin Med. 2023;12. doi:10.3390/jcm12216835
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- Demirtola Aİ, Mammadli A, Çiçek G. The Role of Magnesium Levels in the Progression of Contrast-Induced Nephropathy in Patients With STEMI Undergoing Primary PCI. Angiology. 2025. doi:10.1177/00033197251314629
- Jin Y, Lin Q, Wang D, Gong M, Huang W, et al. Hypomagnesemia is a Risk Factor for Acute Kidney Injury in Patients Admitted With ST-Segment Elevation Myocardial Infarction: A Retrospective Observational Study. J Ren Nutr. 2024. doi:10.1053/j.jrn.2024.12.006
- Naveen V, Rajesh Lenin R, Stanley LM, Kumar JS. Serum Magnesium Levels and QTc Interval Prolongation As Prognostic Markers in Acute Myocardial Infarction: A Randomized Controlled Study. Cureus. 2024;16:e66051. doi:10.7759/cureus.66051
- Zhuang J, Zhang Q, Wang H, Su PH, Chen PY. Association between short-term changes in serum magnesium and in-hospital mortality following acute myocardial infarction: a cohort study based on the MIMIC database. Magnes Res. 2024;37:45. doi:10.1684/mrh.2024.0517
- Zhang J, Sun D, Guo Y, Tong J, Liu Q, et al. Targeted delivery of black phosphorus nanosheets by ROS responsive complex hydrogel based on angiogenesis and antioxidant promotes myocardial infarction repair. J Nanobiotechnology. 2024;22:433. doi:10.1186/s12951-024-02685-0
- Wang B, Pan S, Nie C, Zou R, Liu J, et al. Magnesium implantation as a continuous hydrogen production generator for the treatment of myocardial infarction in rats. Sci Rep. 2024;14:10959. doi:10.1038/s41598-024-60609-2
- Fan C, Qin K, Iroegbu CD, Xiang K, Gong Y, et al. Magnesium lithospermate B enhances the potential of human-induced pluripotent stem cell-derived cardiomyocytes for myocardial repair. Chin Med J (Engl). 2024;137:1857. doi:10.1097/CM9.0000000000002867
- Segev A, Shechter M, Tsur AM, Belkin D, Cohen H, et al. Serum Magnesium Is Associated with Long-Term Survival of Non-ST-Elevation Myocardial Infarction Patients. Nutrients. 2023;15. doi:10.3390/nu15194299
- Włodarczak A, Rola P, Barycki M, Furtan Ł, Łanocha M, et al. Mid-term safety and efficacy of magnesium bioresorbable vascular scaffolds - magmaris in diabetic population. 2-Years outcome in acute coronary syndrome cohort. Diab Vasc Dis Res. 2023;20:14791641231188705. doi:10.1177/14791641231188705
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- An P, Wan S, Luo Y, Luo J, Zhang X, et al. Micronutrient Supplementation to Reduce Cardiovascular Risk. J Am Coll Cardiol. 2022;80:2269. doi:10.1016/j.jacc.2022.09.048
- Evers I, Cruijsen E, Kornaat I, Winkels RM, Busstra MC, et al. Dietary magnesium and risk of cardiovascular and all-cause mortality after myocardial infarction: A prospective analysis in the Alpha Omega Cohort. Front Cardiovasc Med. 2022;9:936772. doi:10.3389/fcvm.2022.936772
- Rola P, Włodarczak A, Łanocha M, Barycki M, Szudrowicz M, et al. Outcomes of the two generations of bioresorbable scaffolds (Magmaris vs. Absorb) in acute coronary syndrome in routine clinical practice. Cardiol J. 2022;30:870. doi:10.5603/CJ.a2022.0047
- Ortega-Paz L, Brugaletta S, Gomez-Lara J, Alfonso F, Cequier A, et al. Magnesium-based resorbable scaffold vs permanent metallic sirolimus-eluting stent in patients with ST-segment elevation myocardial infarction: 3-year results of the MAGSTEMI randomised controlled trial. EuroIntervention. 2022;18:e389. doi:10.4244/EIJ-D-21-00651
- Hasan MZ, Nahar K, Sharif JU, Paul SC, Thakur AK, et al. Serum Magnesium Level and It's Relation in Predicting Adverse In-Hospital Outcome in Patients with First Attack of Myocardial Infarction. Mymensingh Med J. 2023;32:65.
- Fallesen CO, Antonsen L, Maehara A, Noori M, Hougaard M, et al. Optical Coherence Tomography- Versus Angiography-Guided Magnesium Bioresorbable Scaffold Implantation in NSTEMI Patients. Cardiovasc Revasc Med. 2022;40:101. doi:10.1016/j.carrev.2021.12.003
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- Sabaté M, Alfonso F, Cequier A, Romaní S, Bordes P, et al. Magnesium-Based Resorbable Scaffold Versus Permanent Metallic Sirolimus-Eluting Stent in Patients With ST-Segment Elevation Myocardial Infarction: The MAGSTEMI Randomized Clinical Trial. Circulation. 2019;140:1904. doi:10.1161/CIRCULATIONAHA.119.043467
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- Lee TM, Chang NC, Lin SZ. Effect of proton pump inhibitors on sympathetic hyperinnervation in infarcted rats: Role of magnesium. PLoS One. 2018;13:e0202979. doi:10.1371/journal.pone.0202979
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- Ma YT, Laga T, Zhong CN, Zhuang BQ, Quan HL, et al. ANP Increases Zn Accumulation During Reperfusion in Ex Vivo and In Vivo Hearts. Curr Med Sci. 2025;45:35. doi:10.1007/s11596-025-00019-1
- Mohamed ATAE, Ragheb MA, Shehata MR, Mohamed AS. In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production. J Trace Elem Med Biol. 2024;86:127516. doi:10.1016/j.jtemb.2024.127516
- Zhang W, Li Y, Zheng K, Li Y, Yang H. Nonlinear associations between dietary zinc intake and cardiovascular disease risk, a National cross-sectional study based on the NHANES 2005-2018. Prev Med Rep. 2024;45:102830. doi:10.1016/j.pmedr.2024.102830
- Wang S, Wang H, Li L, Niu P, Yin Z, et al. Long-term inhaling ultrafine zinc particles increases cardiac wall stresses elevated by myocardial infarction. Biomed Eng Online. 2024;23:78. doi:10.1186/s12938-024-01275-3
- Zhao H, Liu D, Sun S, Yu J, Bian X, et al. PIAS3 acts as a zinc sensor under zinc deficiency and plays an important role in myocardial ischemia/reperfusion injury. Free Radic Biol Med. 2024;221:188. doi:10.1016/j.freeradbiomed.2024.05.025
- Tanita A, Namiuchi S, Onodera K, Sunamura S, Ogata T, et al. Serum zinc concentration in patients with myocardial infarction: a retrospective study. BMC Cardiovasc Disord. 2024;24:107. doi:10.1186/s12872-024-03776-4
- Zhong Y, Yang Y, Xu Y, Qian B, Huang S, et al. Design of a Zn-based nanozyme injectable multifunctional hydrogel with ROS scavenging activity for myocardial infarction therapy. Acta Biomater. 2024;177:62. doi:10.1016/j.actbio.2024.01.015
- Zhang Y, Li X, Zhang Z, Li H, Chen D, et al. Zn SiO Bioceramic Attenuates Cardiac Remodeling after Myocardial Infarction. Adv Healthc Mater. 2023;12:e2203365. doi:10.1002/adhm.202203365
- Huo Y, Li L. Long-Term Inhalation of Ultrafine Zinc Particles Deteriorated Cardiac and Cardiovascular Functions in Rats of Myocardial Infarction. Front Physiol. 2022;13:921764. doi:10.3389/fphys.2022.921764
